xov xwm

Tam sim no, magnetic resonance imaging (MRI) tab tom txhim kho los ntawm cov qauv qauv duab thiab kev ua haujlwm zoo rau cov duab molecular. Multi-nuclear MR tuaj yeem tau txais ntau yam ntawm cov ntaub ntawv metabolite hauv tib neeg lub cev, thaum tswj kev daws teeb meem spatial, txhim kho qhov tshwj xeeb ntawm kev tshawb pom ntawm lub cev thiab cov txheej txheem pathological, thiab tam sim no tsuas yog thev naus laus zis uas tuaj yeem tsis cuam tshuam ntau qhov kev soj ntsuam ntawm tib neeg cov metabolism hauv molecular hauv vivo.

Nrog rau kev sib sib zog nqus ntawm ntau cov tub ntxhais MR Kev Tshawb Fawb, nws muaj cov ntawv thov dav dav hauv kev tshuaj ntsuam ntxov thiab kuaj mob qog nqaij hlav, kab mob plawv, kab mob neurodegenerative, endocrine system, digestive system thiab cov kab mob ua pa, thiab kev soj ntsuam ceev ntawm cov txheej txheem kho mob. Philips 'cov kev tshawb fawb ntau qhov chaw kho mob tshiab kawg yuav pab cov duab thiab cov kws kho mob ua tiav cov kev tshawb fawb soj ntsuam. Dr. Sun Peng thiab Dr. Wang Jiazheng los ntawm Philips Clinical thiab Technical Support Department tau muab cov ncauj lus qhia ntxaws txog kev tsim kho tshiab ntawm multi-NMR thiab cov kev taw qhia tshawb fawb ntawm Philips 'tshiab multi-core MR Platform.

Sib nqus resonance tau yeej qhov Nobel nqi zog tsib zaug hauv nws keeb kwm, thoob plaws thaj chaw ntawm physics, chemistry, biology, thiab tshuaj, thiab tau ua tiav zoo hauv cov ntsiab lus physics, cov qauv ntawm cov organic molecular, cov qauv ntawm cov macromolecular, thiab kev kho mob imaging. Ntawm lawv, magnetic resonance imaging tau dhau los ua ib qho tseem ceeb tshaj plaws hauv kev kho mob imaging technologies, dav siv nyob rau hauv kev kuaj mob ntawm ntau yam kab mob nyob rau hauv ntau qhov chaw ntawm tib neeg lub cev. Nrog rau kev txhim kho txuas ntxiv ntawm cov kev xav tau kev noj qab haus huv, qhov kev thov loj rau kev kuaj mob ntxov thiab kev ntsuas kev ua tau zoo sai yog txhawb kev txhim kho ntawm magnetic resonance imaging los ntawm cov qauv duab ib txwm muaj (T1w, T2w, PDw, thiab lwm yam), kev ua haujlwm imaging (DWI, PWI, thiab lwm yam) rau molecular imaging (1H MRS / multi-MRS).

Cov keeb kwm nyuaj ntawm 1H raws li MR Technology, sib tshooj spectra, thiab dej / rog compression txwv nws qhov chaw raws li kev siv tshuab molecular. Tsuas yog qee tus lej ntawm cov molecules (choline, creatine, NAA, thiab lwm yam) tuaj yeem kuaj pom, thiab nws nyuaj kom tau txais cov txheej txheem dynamic molecular metabolic. Raws li ntau yam nuclides (23Na, 31P, 13C, 129Xe, 17O, 7Li, 19F, 3H, 2H), multi-nuclear MR tuaj yeem tau txais ntau yam ntawm cov ntaub ntawv metabolite ntawm tib neeg lub cev, nrog kev daws teeb meem siab thiab qhov tshwj xeeb, thiab tam sim no tsuas yog cov xov tooj cua tsis muaj qhov kawg nkaus xwb; metabolites (qabzib, amino acids, fatty acids - non-toxic) rau kev soj ntsuam ntau ntawm tib neeg cov txheej txheem molecular metabolic.

Nrog rau kev ua haujlwm tsis tu ncua hauv kev sib nqus resonance hardware system, txoj kev nrawm nrawm (Multi-Band, Kauv) thiab acceleration algorithm (compressed sensing, deep learning), multi-core MR Imaging/spectroscopy yog maj mature: (1) nws yuav tsum yog ib qho tseem ceeb rau kev txiav-ntug molecular biology tib neeg, kev tshawb fawb biochemistry. (2) Raws li nws txav los ntawm kev tshawb fawb txog kev tshawb fawb mus rau kev kho mob (ntau qhov kev sim tshuaj raws li ntau tus tub ntxhais kawm MR tab tom ua tiav, FIG. 1), nws muaj kev cia siab dav hauv kev kuaj ntxov ntxov thiab kuaj mob qog noj ntshav, mob plawv, neurodegenerative, digestive thiab ua pa kab mob, thiab kev ntsuam xyuas sai.

Vim yog lub hauv paus ntsiab lus ntawm lub cev thiab kev nyuaj siab ntawm MR Field, multi-core MR tau ua ib qho kev tshawb fawb tshwj xeeb ntawm ob peb lub tsev tshawb fawb engineering saum toj kawg nkaus. Txawm hais tias multicore MR tau ua kom muaj kev vam meej tom qab ntau xyoo ntawm txoj kev loj hlob, tseem tsis muaj cov ntaub ntawv kho mob txaus los txhawb txoj haujlwm no kom pab cov neeg mob tiag tiag.

Raws li kev tsim kho tshiab tsis tu ncua hauv kev ua haujlwm ntawm MR, Philips thaum kawg tau rhuav tshem txoj kev loj hlob ntawm cov tub ntxhais MR thiab tso tawm ib qho kev tshawb fawb soj ntsuam tshiab nrog cov nuclides feem ntau hauv kev lag luam. Lub platform tsuas yog ntau lub hauv paus hauv ntiaj teb kom tau txais EU Safety Conformity Certification (CE) thiab US Food and Drug Administration (FDA) certification, enabling a product-level full-stack multi-core MR Solution: FDA-pom zoo coils, tag nrho sequence coverage, and operator station standard reconstruction. Cov neeg siv tsis tas yuav tsum tau nruab nrog cov kws tshaj lij magnetic resonance physicists, code engineers thiab RF gradient designers, uas yooj yim dua li ib txwm 1H spectroscopy / duab. Txhim kho qhov txo qis ntawm ntau cov tub ntxhais MR kev khiav hauj lwm cov nqi, kev hloov pauv dawb ntawm kev tshawb fawb thiab kev kho mob hom, tus nqi rov qab sai tshaj plaws, kom cov tub ntxhais ntau MR muaj tseeb rau hauv tsev kho mob.

Multi-core MR Tam sim no yog cov kev taw qhia tseem ceeb ntawm "14th Tsib-Xyoo Cov Khoom Siv Kho Mob Kev Lag Luam Kev Txhim Kho Kev Lag Luam", thiab yog ib qho tseem ceeb thev naus laus zis thev naus laus zis rau kev kho mob kom ua tiav txoj haujlwm niaj hnub thiab ua ke nrog cov tshuaj biomedicine. Philips Tuam Tshoj cov kws tshawb fawb pab pawg, tau tsav los ntawm kev txhim kho cov neeg siv khoom kev tshawb fawb thiab kev tsim kho tshiab, tau ua cov kev tshawb fawb txog kev ua haujlwm ntawm ntau tus tub ntxhais MR. Dr. Sun Peng, Dr. Wang Jiazheng et al. thawj lub tswv yim ntawm MR-nucleomics hauv NMR hauv Biomedicine (sab saum toj Journal of the First Region of Spectroscopy of Chinese Academy of Sciences), uas tuaj yeem siv MR Raws li cov nuclides sib txawv los soj ntsuam ntau yam ntawm tes ua haujlwm thiab cov txheej txheem pathological. Yog li, kev txiav txim siab thiab kev ntsuam xyuas ntawm cov kab mob thiab kev kho mob tuaj yeem ua tau [1]. Lub tswv yim ntawm MR Multinucleomics yuav yog qhov kev taw qhia yav tom ntej ntawm MR Development. Daim ntawv no yog thawj qhov kev tshuaj xyuas ntawm ntau tus tub ntxhais MR Hauv ntiaj teb, suav nrog lub hauv paus theoretical ntawm ntau cov tub ntxhais MR, kev tshawb fawb ua ntej, kev hloov kho kho mob, kev txhim kho kho vajtse, kev nce qib algorithm, kev coj ua engineering thiab lwm yam (Daim duab 2). Nyob rau tib lub sijhawm, pab pawg kws tshawb fawb tau koom tes nrog xibfwb Song Bin ntawm West China Tsev Kho Mob kom ua tiav thawj tsab xov xwm tshuaj xyuas txog kev hloov kho ntawm ntau tus tub ntxhais kawm MR Hauv Suav teb, uas tau luam tawm hauv phau ntawv Journal Insights into Imaging [2]. Kev tshaj tawm ntawm cov ntawv xov xwm ntawm multicore MR Qhia tau tias Philips tiag tiag coj lub ntsej muag ntawm multicore molecular imaging rau Tuam Tshoj, rau Suav cov neeg siv khoom, thiab rau cov neeg mob Suav. Raws li lub tswv yim tseem ceeb ntawm "hauv Tuam Tshoj, rau Tuam Tshoj", Philips yuav siv ntau lub ntsiab lus MR los txhawb txoj kev loj hlob ntawm Tuam Tshoj txoj kev sib nqus resonance thiab pab ua kom muaj kev noj qab haus huv ntawm Tuam Tshoj.

Multi-nuclear MRI yog ib qho kev siv technology tshiab. Nrog rau kev txhim kho ntawm MR Software thiab kho vajtse, multi-nuclear MRI tau siv rau hauv kev tshawb fawb thiab kev kho mob txhais lus ntawm tib neeg lub cev. Nws qhov tshwj xeeb kom zoo dua yog tias nws tuaj yeem tso saib cov txheej txheem metabolic hauv lub sijhawm tiag tiag hauv cov txheej txheem pathological sib txawv, yog li muab kev muaj peev xwm rau kev kuaj mob ntxov ntawm cov kab mob, kev ntsuas kev ua tau zoo, kev txiav txim siab kho mob thiab kev txhim kho tshuaj. Nws tseem tuaj yeem pab tshawb nrhiav cov txheej txheem tshiab ntawm pathogenesis.

Txhawm rau txhawb txoj kev loj hlob ntxiv ntawm daim teb no, kev koom tes ntawm cov kws kho mob yog xav tau. Kev kho mob ntawm multicore platforms yog qhov tseem ceeb, nrog rau kev tsim kho ntawm cov txheej txheem hauv paus, kev ua qauv ntawm cov thev naus laus zis, kev tsim kom muaj nuj nqis thiab cov qauv ntawm cov txiaj ntsig, kev tshawb nrhiav cov kev tshawb fawb tshiab, kev sib koom ua ke ntawm ntau cov ntaub ntawv metabolic, thiab lwm yam, ntxiv rau kev txhim kho ntawm ntau lub zeem muag multicenter kev sim, txhawm rau txhawm rau txhawb kev kho mob ntau yam kev hloov pauv ntawm MR Technology. Peb ntseeg siab tias ntau tus tub ntxhais MR Yuav muab cov theem dav rau kev kuaj pom thiab cov kws kho mob los ua cov kev tshawb fawb soj ntsuam, thiab nws cov txiaj ntsig yuav muaj txiaj ntsig zoo rau cov neeg mob thoob ntiaj teb.